My research is driven by the following intriguing question: how can we establish, maintain and regulate the interactions between humans and agents (e.g., machines, and humans) for desired outcomes? A critical step toward answering this question is to understand the roles of incentives, information and institutions in multi-agent interactions at scale. To this end, I delve into the interdisciplinary research that spans multi-agent systems, game theory, human-agent interaction, and social computing. My current work focuses on: (1) resilient mechanism design, and its application to online platforms and networks where agents may not be able to obtain perfect rationality; (2) strategic diffusion in large-scale networks with application to advertisement, auctions, and cybersecurity; and (3) online learning in strategic decision making. Typical methodologies include information design, mechanism design, social influence network theory, learning and optimization in sequential decision making, and multi-agent simulation.